Wayne Arnold was previously European chief executive, before moving to New York in 2008 to launch Profero's North America office. He will take on his new role in mid-July.
Daryl Arnold said: "As an entrepreneur, now is the time for me to hand the leadership of the business I founded to my brother Wayne, who I know will drive Profero forward to still greater success and acclaim. I will continue to be a leading shareholder and, naturally, support Profero in my capacity as a founder."
He co-founded Profero with Wayne in 1998 and currently holds a 36 per cent shareholding in the group. In the nine months to December 2008, the group reported turnover of US$35 million, with a gross income of US$13 million.
Profero is an independent digital agency founded in London and currently has 15 offices across Europe, Asia and the USA. In Asia, Profero has operations in all the major markets including Singapore, Hong Kong, Shanghai, Beijing, Tokyo and Sydney in working with large brands including P&G, Virgin, Johnson & Johnson, Guiness and Pizza Hut, among others.