The hubs will include both Mindshare and Google employees working across all aspects of the mobile ecosystem, from search optimisation and app development to strategy, planning and creative optimisation.
The 'Mobile garage' initiative will initially be introduced in Singapore, London and New York.
Mindshare said the initiative will give its clients a unique, competitive advantage in a key battleground.
Mobile search traffic has increased by 400 per cent over the past two years, Mindshare said, adding that GSMA and Machina predict the industry will be worth $4.5 trillion by 2020.
Nick Emery, CEO of Mindshare Worldwide, said, "We designed Mindshare to be open source and to work with the best partners for the benefit of our clients. It’s about trial, experimentation and speed to re-design our business.”